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KMID : 0869120060080010005
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기초간호자연과학회지
2006 Volume.8 No. 1 p.5 ~ p.14
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Antibiotic Resistance of Staphylococcus Aureus
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Kim Yun-Kyung
Jeong Jae-Sim
Hong Hae-Sook
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Abstract
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Staphyloccus aureus is one of the most important pathogens in clinical settings. It is also one of the leading causes of nosocomial infections and the dissemination of multiple drug-resistant strains, mainly methicillin resistant Staphyloccus aureus, and the recent emergence of a vancomycin resistant MRSA is the concern to hospital worldwide.
MRSA strains have acquired multiple resistance to a wide range of antibiotics, including aminoglycosides and macrolides. β-Lactam resistance of methicillin-resistnat Staphyococcus aureus is determined by the function of penicillin binding protein 2’(PBP2’) encoded by the methicillin resistance gene mec A. MRSA strains carry methicillin resistance gene mecA, encoded by a mobile genetic element designated staphylococcal cassette chromosome mec(SCCmec). MRSA clones are defined by the type of SCCmec element and the genotype of the methicilline-susceptible Staphyococcus aureus chromosome in which the SCCmec element is integrated.
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KEYWORD
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staphylococcus aureus, antibiotic resistance
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